Rare Double Heterozygous of HbD/HbG in a Nigerian: A Case Report

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Olusogo Ebenezer Busari
Taiwo Rachael Kotila
Omotola Toyin Ojo

Abstract

Aim: To advocate the use of newer and improved methods towards accurate diagnosis of haemoglobinopathies


Case Presentation: A rare case of double heterozygous of HbD/G in a pregnant female Nigerian who had present to the antenatal clinic for routine Haemoglobin electrophoresis. She had previously been diagnosed as HbAS using capillary electrophoresis and HPLC techniques.


Discussion: Capillary zone electrophoretograms showed the presence of peaks in zone Hb A, Hb D, C and a small peak in Z1 zone. Bio-Rad D10 chromatogram also indicated the presence of four peaks which are identified as Hb A, Hb D, Hb G, and hybrid of HbD/HbG. A peak in Hb D zone of capillary electrophoresis was due to co-migration of Hb D and Hb G variants. The small peak in Z1 zone indicated the presence of alpha chain variant of HbG.


Conclusion: The case exemplifies the need to use more advanced methods, including DNA analysis in order to accurately diagnose haemoglobinopathies in the nation with the largest burden of sickle cell disease.

Keywords:
Haemoglobinopathies, haemoglobin electrophoresis, heterozygous, high performance liquid chromatography

Article Details

How to Cite
Busari, O., Kotila, T. R., & Ojo, O. T. (2018). Rare Double Heterozygous of HbD/HbG in a Nigerian: A Case Report. International Journal of Research and Reports in Hematology, 1(1), 1-6. Retrieved from http://journalijr2h.com/index.php/IJR2H/article/view/25643
Section
Case Study