Influence of Age Category and Malaria Type on Some Haematological, VWF, ADAMTS13, L-arg, D2D, FBG, FVIII and Coagulatory Parameters of Malaria Infected Paediatric Subjects in Rivers State, Nigeria

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S. O. Akwuebu
B. S. Mbeera
N. C. Ibeh
E. M. Eze
Z. A. Jeremiah


Aim: The aim of the study was to assess the influence of age category and malaria type on haematological and haemostatic parameters in malaria infected children resident in Rivers State, Nigeria.

Study Design:  The study was cross-sectional observational study.

Place and Duration of Study: University of Port Harcourt Teaching Hospital, Rivers State, Nigeria, between the month of March and August 2020. 

Methodology: A total of 822 pediatrics (0-16 years), were randomly selected for this study after due parental consent. 5ml of venous blood was collected from each subject: 1ml was dispensed into paediatric EDTA (for haematologic and parasite density) and 4ml into sodium citrate bottle for L-arginine assay by ELISA-method, while Full blood count was determined using haematological auto-analyser, Mindray BC-6800. Malaria density was determined by microscopic method using thick and thin Giemsa stained blood smears. Level of significance was set at P<0.05.

Results: The results showed that there were significant (p<.001) decreased in WBC & NEU in neonate and adolescent and increased in children when compared with the control subjects of uncomplicated and complicated malaria. EOS was observed to have a significant (p< 0.0065) increased in the age categories; (neonates, children and adolescent) however complicated malaria subjects were observed to have a significant (p<.05) decreased EOS when compared with the uncomplicated malaria. In addition, there was no significant (p>0.05) different in the mean PT, PTT, INR, ADAMT13, and FViii in the three age categories. However, FBG, VWF and D2D were observed to be significantly (p<.05), (p<.05), (p<.001) increased in the age categories being highest in children.

Conclusion: In conclusion, haematological parameters decreased as malaria got complicated in neonates, increased in children, while haemostatic parameters such as VWF, FBG and D2D increased in the three age categories being highest in children.

Age category, malaria, haematologic and haemostatic parameters, paediatric, Rivers State, Nigeria

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Akwuebu, S. O., Mbeera, B. S., Ibeh, N. C., Eze, E. M., & Jeremiah, Z. A. (2021). Influence of Age Category and Malaria Type on Some Haematological, VWF, ADAMTS13, L-arg, D2D, FBG, FVIII and Coagulatory Parameters of Malaria Infected Paediatric Subjects in Rivers State, Nigeria. International Journal of Research and Reports in Hematology, 4(1), 42-52. Retrieved from
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