Assessment of Some Systemic Inflammatory Markers and Haematological Parameters among Pregnant Women in Different Trimesters in Port Harcourt, Nigeria
International Journal of Research and Reports in Hematology,
Pregnancy is a physiological condition that is associated some changes in haematological and immunological parameters. This study evaluated the levels of some systemic inflammatory and haematological parameters in pregnant women in Port Harcourt, Nigeria. A total of 275 pregnant women of age 20 to 70 years and 87 apparently healthy non-pregnant control subjects were involved in this study. Five millilitres (5ml) of blood were collected from the subjects into EDTA bottle for the evaluation of the parameters. ELISA technique was used in the determination of soluble transferrin receptor while Sysmex automation was used for the determination of the other parameters. The mean value of parameters for the study subjects were Hb( 9.05± 1.22g/dl), sTfR( 21.16± 9.11nmol/L), NLR (2.69 ± 0.91), PLR (8.78 ± 2.97), while for control subjects were Hb( 12.19± 0.66g/dl), sTfR( 18.21± 3.77nmol/L), NLR (2.86 ± 0.11), PLR (9.62 ± 2.79). The mean sTfR levels in pregnant women was significantly lower (p=0.001) than in control subjects. The pregnant women also had significantly lower values of Hb (p=0.0001), and PLT (p=0.017). According to trimesters, the levels of sTfR significantly increased with trimester (p=0.002), while that of PLR significantly increased in the second trimester (p=0.006). However, there were no significant differences in the levels of Hb (p=0.185) and NLR (p=0.70) among the trimesters. The results indicate that the pregnant women did not have levels of parameters that may indicate negative outcomes of pregnancy. It is recommended that systemic parameters be monitored among pregnant women in order to help in their medical management.
- Systemic inflammatory markers
- pregnant women
- Port Harcourt
- haematological parameters
How to Cite
Gwarzo MY, Ugwa EA. The pattern of anaemia in |Northern Nigerian pregnant women. Journal of Medicine and Medical Sciences, 2013;4(8):319 – 323.
Kaur S, Khan S, Nigam A. Haematological profile and pregnancy: A review. International Journal of Advances in Medicine. 2014;1(2):68 – 70.
Bernstein IM, Ziegler W, Badger GJ. Plasma volume expansion in early pregnancy. Journal of Obstetrics and Gynocology. 2011;97:669.
Nadeau-Vallee M, Obari D, Palacios J, Brien M, Duval C, Chemtob S, Girard S. Sterile inflammation and pregnancy complications: A review. Reproduction. 2016;152(6):R277-R292
Romero R, Miranda J, Chaiworapongsa T, Korzeniewski SJ, Chaemsaithong P, Gotsch F. Prevalence and clinical significance of sterile intra-amniotic inflammation in patients with preterm labor and intact membranes. American Journal of Reproductive Immunology. 2014; 72:458-74
Hai L, Hu Z.D. The clinical utility of neutrophil to lymphocyte ratio in pregnancy related complications: a mini-review. Journal of Laboratory and Precision Medicine. 2020;5:1
Lurie S, Rahamim E, Piper R, Golan A, Sadam O. Total and differential leukocyte counts percentiles in normal pregnancy. European Journal of Obstetrics Gynaecology and Reproductive Biology. 2008;136(1):16 – 19.
Osonuga IO, Osunuga OA, Onadeko AA, Osonuga A, Osonuga AA. (2011). Haematological profile of pregnant women in Wouth West of Nigeria. Asian Pacific Journal of Tropical Diseases. 2011;1:232–234
Gibson PH, Cuthbertson BH, Croal BL, Rae D, El-Shafei H, Gibson G. Usefulness of neutrophil/lymphocyte ratio as a predictor of new-onset atrial fibrillation after coronary artery bypass grafting. Am J Cardiol 2010;105:186-191.
Çakıroğlu Y, Vural F, Vural B. The inflammatory markers in polycystic ovary syndrome: association with obesity and IVF outcomes. J Endocrinol Invest. 2016;39(08):899–907
Biyik I, Albayrak M, Keskin F. Platelet to lymphocyte ratio and neutrophil to lymphocyte ratio in missed abortion. Revista Brasileira de Ginecologia e Obstetricia. 2020;42(5):235-239
Birnbach DJ, Browne IM. Anaesthesia for obstetrics. In Miller, Rd, Eriksson, LI, Fleisher, LA, Weiner-Kronish, JP, Young, WL (Eds). Miller’s Anaesthesia (7th Ed.). USA. Churchill Livingstone Elsevier.2020;2204-2206
Grewal A. Anaemia and pregnancy: Anaesthetic implications. Indian Journal of Anaesthesiology. 2010;54(5):380-386
Ma A, Chen X, Zheng M, Wang Y, Xu R, Li J. Iron status and dietary intake of Chinese pregnant women with anemia in the third trimester. Asia Pacific Journal of Clinical Nutrition. 2002;11(3):171-175
Block CEM, Campenhout CMV, Leeuw IH, Keenoy BM, Martin M, Hoof VV, Gaal LFV. Soluble transferring receptor level: a new marker of iron deficiency anaemia, a common manifestation of gastric autoimmunity in type 1 diabetes. Diabetes Care. 2000;23:1384-1388.
Bakrim S, Motiaa Y, Ouarour A, Masrar A. Haematological parameters of the blood count in a healthy population of pregnant women in the Northwest of Morocco (Tetouan-M’-diq-Fnideq provinces). The Pan African Medical Journal.2018;29:205
Geetanjali P, Trushna S, Harsoda JM. Hematological profile of normal pregnant women in Western India. Scholars Journals of Applied Medical Science. 2015;3(6A):2195–2199.
Gökçen Ö, Burcu S, Oytun P, Meral BM, Sinan B. Total Blood Lymphocyte Count Alteration During and after Pregnancy. Gynecology, Obstetrics and Reproductive Medicine. 2017; 23(1):11–13.
Akinbami AA, Ajibola SO, Rabiu KA, Adewunmi AA, Dosunmu AO, Adediran A, Osunkalu VO, Osikomaiya BI, Ismail KA. Hematological profile of normal pregnant women in Lagos, Nigeria. International Journal of Women’s Health. 2013;5:227-232
Dogar MZ, Latif I, Saba A, Kanwal S, Khan AH, Zhan ZI, Ahmad K. Evaluation of iron supplementation effects on various hamatoloical parameters in pregnant anaemic patients of Sargodha region in Pakistan. Journal of Environmental and Analytical Toxicology. 2013;3(4):2 – 5
Okafor IM, Antai AB, Okpokam DC, Usanga EA. Soluble transferrin receptor as a marker in the diagnosis of iron deficiency anaemiain pregnancy: A study in Calabar, Nigeria. International Journal of Biomedical Laboratory Science. 2014;3(2):41-46
R’zik S, Loo M, Beguin Y. Reticulocyte, transferrin receptor expression and contribution to soluble transferring levels. Haematologica: 2001;86:244 – 251.
Chandra, F, sun, L. Iron status and choice of iron therapy during pregnancy: Advantages and disadvantages. International Journal of Reproduction, Contraception, Obstetrics and Gynaecology, 2015;4(5):1264–1271.
Choi JW. Serum transferrin receptor concentrations during normal pregnancy. Clinical Chemistry. 2000;46(5):725 – 727
Bothwell TH. Iron requirements in pregnancy and strategies to meet them. American Journal of Clinical Nutrition. 2000;72:257–264.
Miller EM. The reproductive ecology of iron in women. American Journal of Physical Anthropology. 2016;159(61):172-195
Dogan S, Turkoglu I. Iron deficiency anaemia detection from haematology parameters by using decision trees. International Journal of Science and Technology. 2008;3(1):85-92
Gogoi P, Sinha P, Gupta B, Firmal P, Rajaram S. Neutrophil-to-lymphocyte ratio aand platelet indices in pre-eclampsia. International Journal of Gynaecology and Obstetrics. 2019;144(1):16-20
Yilmaz H, Ceik HT, Namuslu M, Inan O, Onaran Y, Karakurt Y, Ayyildiz F, Bilgic MA, Bavbek N, Akcay A. Benefits of the neutrophil-to-lymphocyte ratio for the prediction of gestational diabetes mellitus in pregnant women. Experimental and Clinical Endocrinology and Diabetes. 2014;122(1):39-43
Qiao S, Gao W, Guo S. Neutrophil-lymphocyte ratio for predicting clinical outcomes in patients with coronary artery disease and type 2 diabetes mellitus: A propensity score matching analysis. Therapeutics and Clinical Risk Management. 2020;437-443.
Ozdemir ED, Ozdemir H. Evaluation of correlations of maternal systemic inflammatory markers such as neutrophil to lymphocyte ratio and platelet to lymphocyte ratio with gestational age. Tropical Journal of Obstetrics and Gynaecoogy. 2020;37(1):62-66
Forget P, Khalifa C, Defour JP, Latinne D, van Pel MC, de Kock M. What is the normal value of the neutrophil-to-lymphocyte ratio? BMC Res Notes. 2017;10:12
Jaffer DW, Rabie MA. Maternal platelet-to-lymphocyte ratio at delivery can predict poor neonatal outcome in preterm births. Turkish Journal of Obstetrics and Gynaecology. 2018;15: 254-258
Danielsen I, Granstrom C, Rytter D, Halldorsson T.I, Bech B.H, Henriksen TB, Stehouwer CDA, Schalkwijk CG,Vaag AA,Olsen SF. Subclinical inflammation during third trimester of pregnancy was not associated with markers of the metabolic syndrome in young adult offspring. 2013; 22(5):1351-1358
Hershko KA, Hadi E, Asali A, Shavit T, Wiser A, Haikin E, Barkan Y, Biron-Shental T, Zer A, Gadot Y. Neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in pregnancy: A population study. Plos One. 2018;13(5):e196706
Yucel B and Ustun B. (2017). Neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, mean platelet volume, red cell distribution width and plateletcrit in preeclampsia. Pregnancy and Hypertension. 2017;7:29-32.
Abstract View: 249 times
PDF Download: 104 times