Impact of (ELIOZU) Dumpsite Leachates on Some Haematological Parameters in Wistar Rats
International Journal of Research and Reports in Hematology,
Leachates contain deleterious constituents that may cause contamination of ground and surface water leading to serious risks to the ecosystem and human health. The exposure of the environment to dumpsite leachate may occur in different ways, such as uncontrolled overflow, rainfall and infiltration. This study therefore, attempts to determine the possible effects of (Eliozu) dumpsite leachates on some haematological parameters in Wistar rats. 25 Wistar rats weighing between 180g and 250g were divided into five groups of 5 animals each. Groups are as follows: Group 1: received 1ml of commercial bottle water, Group 2: received near-by borehole water, Group 3: received 10% of leachate concentrations, Groups 4 and 5: received 50% and 100% of leachate concentrations every 24 hours for 90 consecutive days. At the end of the gavaging of the leachates, blood samples were collected for heamatological parameters analysis using automated method. Results obtained shows a significant (p<0.001) reduction in some hematological parameters compared with control. Paradoxically, the mean corpuscular volume (MCV), red blood cell distribution width-standard deviation and red blood cell distribution width-coefficient of variation show significant increase (p<0.001) compared with the control. There were also significant decreases in weights of the experimental animals while compared with the control group. Eliozu dumpsite leachates demonstrated some toxicological potentials on Red Blood Cells (RBCs) and RBC indices; White Blood Cells (WBCs) and WBC Differentials in Wistar rats. We recommend further studies in this regard.
- Eliozu Dumpsite
How to Cite
Pivato A, Gaspari L. Acute Toxicity Test of leachates from traditional and sustainable landfills using luminescent bacteria. Waste Management. 2006;26: 1148-1155.
Ogundiran OO, Afolobi TA. Assessment of the physicochemical parameters and heavy metals toxicity of leachates from municipal solid waste open site. International Journal of Environmental Science. Technology. 2008;5(2):243-245.
Abd EL Rhiem, A Ashour, Maged, M. Yassin., Nahed, M. Abu, AASI., Rokaya, M. Ali Blood, serum glucose and renal parameters in lead-loaded Albino Rats and Treatment with some Chelating agents and Natural oil. Turkish Journal of Biology. 2007;31(25):25-34.
Al Sabbagh MK, Velis CA, Wilson DC, Cheeseman CR. Resource management performance in Bahrain: A systematic analysis of municipal waste management, secondary material flows and organizational aspects. Waste Management. Research. 2012;30:813–824.
Alam R, Chowdhury MAI, Hasan GMJ, Karanjit B, Shrestha LR. Generation, storage, collection and transportation of municipal solid waste–A case study in the city of Kathmandu,capital of Nepal.Waste Management. 2008;28: 1088–1097.
Alimba CG, Gandhi D, Sivannesen S. Bhanarkar MD, Naoghare PK, Bakere AA, Krishnamorthi K. Chemical characterization of simulated landfill soil leachates from Nigeria and India and their cytotoxicity and DNA damage inductions on three human cell lines. Chemosphere. 2016;164:469-479.
Brockus CW. Erythrocytes. In Duncan and Prasse’s Veterinary laboratory medicine: Clinical Pathology, Edition Latiner. KS, 5th Edition Wiley Chichester, UK. 2011;3-44.
Institute for Laboratory and Animal Research. Guide for the care and use of Laboratory Animals. Seventh Edition. National Academies Press. Washington DC, USA; 1996.
Jones ML, Alison RW. Evaluation of the ruminant complete blood cell count. Veterinary Clinic. North American Food and Animal Practice. 2007;23:377-402.
Kinikanwo I, Green Oriji K, Vaduneme weleh I. Ikechukwu. Impact of Eliozu Port Harcourt Landfill Leachate on Some Reproductive Hormones in Female Wistar Rats. International Journals of Research and Reports in Gynecology. 2020;3(1):20-24.
Nagara KE, Nakayama, Obayashi H. Experimental studies on toxicity of ethylene glycol monomethyl ether in Japan. Environmental Health prospective. 1984;57:75-84.
Oseni BS, Togun Taiwo VA. Effect of Marijuana Smoking on some Haematological parameters of smokers. World Journal of Medical. Science. 2006;1 (2):82-85.
Vincenzo Torretta, Navarro Ferronata, Ioannis A. Katsoyiannis, Anthanasia K. Tolkou and Michela Airoldi. Novel and conventional technologies for landfill leachates treatment. A Review; 2016.
Guerrero LA, Maas G, Hogland W. Solid waste management challenges for cities in developing countries. Waste Management. 2013;33: 220–232.
Chatham-Stephens K, Caravanos J, Ericson B, Landrigan P, Fuller R. The pediatric burden of disease from lead exposure at toxic waste sites in low and middle income countries. Environmental. Research. 2014;132:379–383.
Pablos MV, Martini F, Fernandez C, Babin MM, Herraez I, Miranda J. Correlation between physicochemical and ecotoxicological approaches to estimate landfill leachates toxicity. Waste Management. 2011;31:1841–1847.
Claudia Regina Klauck, Marco Antonio Siqueira Rodrigues and Luciano Basso da Silva. Toxicological evaluation of landfill leachate using plant (Allium Cepa) and fish (Leporinus Obtusidens) bioassays. International solid waste Association. (internet); 2013.
Owhoghere-Asuma O, Aweto KE. Leachate characterization and Assessment of Groundwater and surface water Qualities near Municipal Solid waste Dump site in Effurun, Delta State. Nigeria. Journal of Environmental and Earth Science. 2012;3.
Anshu Gupta, Paulraj. Toxicity Assessment of municipal solid waste landfill leachate collected in different seasons from Okhala landfill site of Delhi. Journal of Biomedical Sciences and Engineering. 2015;8:357-369.
Vinodhini R, Narayanan M. Bioaccumulation of heavy metals in organs of fresh water fish Cyprinus Carpio (common carp). International journal of Experimental science and technology. 2008;5(2):179-182.
Sharma NP, Dubey UM. Hepatoprotective and antioxidative property of Andrographs paniculata in BHC induced liver damage in mice Indian Journal of Experimental Biology. 2007;39 41-46.
Iyke I, Weleh Owunari. A Georgewill, Victor D Dapper. Effect of Port Harcourt (Eliozu) Landfill leachates on Oxidative Stress Using Oxidative Stress Markers in Wistar rats. Journal of Environmental Science, Toxicology and Food Technology (IOSR-JESTFT). 2020;13(4):PP01-04.
Chibuisi G, Alimba, Adekunle A. Bakare and Olatubosun G. Arinola. Effect of municipal solid waste leachate on leucocyte and Differential counts in rats. Global journal of Environmental Research. 2009;3(3):135-140
Oseni VA, Togun, OF, Taiwo. Affect Marijuana smoking on some haematological parameters of smokers. World. Journal of Medical Science. 2006;1(2):82-85.
Brent-Moore. Marijuana associated with some respiratory symptoms as tobacco. In: S.O; 2005.
Guangke LI, Sang N, and Li GK. Chromosomal aberrations induced in Mouse bone marrow cells by municipal landfill leachate. Environmental toxicology and pharmacology. 2005;20:219-224.
Li G, Sang N, Guod. Oxidative damage induced in hearts, kidney and spleens of mice by landfill leachate. Chemophere. 2006;65(6):1058-1063.
Abstract View: 47 times
PDF Download: 28 times