Neutrophils to Lymphocytes Ratio and Some Cytokines in Patients with Schizophrenia in Southeast, Nigeria

Emmanuel Ifeanyi Obeagu; Ayodeji David Johnson; Onyinye Cecilia Arinze-Anyiam; Arinze Favour Anyiam; Gina Flor Ramos; Bessie Nonyelum Esimai

Neutrophils to Lymphocytes Ratio and Some Cytokines in Patients with Schizophrenia in Southeast, Nigeria

Emmanuel Ifeanyi Obeagu

Ayodeji David Johnson

Onyinye Cecilia Arinze-Anyiam

Arinze Favour Anyiam

Gina Flor Ramos

Bessie Nonyelum Esimai

International Journal of Research and Reports in Hematology, Page 107-112

Published: 30 May 2022

Abstract

Schizophrenia is likely to be associated with immunological abnormalities. The aim of the study is to investigate the changes in NLR and some cytokines of patients with schizophrenia in Southeast, Nigeria. A total number 100 subjects were recruited for the study comprising 50 for the patients with Schizophrenia and 50 apparently healthy subjects both aged 25 – 60 years. Blood was collected from each subject and levels of cytokines were measured by Enzyme Linked Immunosorbent Assay WBC (x10⁹/L), Neutrophils and Lymphocyte were measured using manual counting method. Interleukin - 6, TNF-α, WBC and Neutrophil values were significantly higher in Schizophrenic subjects than control subjects (p=0.00, 0.00, 0.00, and 0.001) respectively. Lymphocyte value was lower than control subjects (p<0.05). NLR was higher in patients with Schizophrenia than the control. In conclusion, there were significantly higher values in IL-6, WBC and Neutrophil levels of schizophrenic subjects when compared apparently healthy subjects.

Keywords:

Immunological abnormalities
neutrophil levels
schizophrenia
cytokines

How to Cite

Obeagu, E. I., Johnson, A. D., Arinze-Anyiam, O. C., Anyiam, A. F., Ramos, G. F., & Esimai, B. N. (2022). Neutrophils to Lymphocytes Ratio and Some Cytokines in Patients with Schizophrenia in Southeast, Nigeria. International Journal of Research and Reports in Hematology, 5(2), 107-112. Retrieved from https://journalijr2h.com/index.php/IJR2H/article/view/30171

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