Blood Cells Formative Properties of B. pinnatum in Chronic Inflammatory Disorders: An Experience with Wistar Rats
International Journal of Research and Reports in Hematology,
The use of medicinal plants to resolve many ailments especially inflammatory diseases is gaining global attention. Bryophyllum pinnatum(Crassulaceae) called ‘Oda-opue’ in Igbo, ‘Eru-odundun in Yoruba and ‘Abomoda’ in Hausa languages is one of the plants widely used as food and medicines in tropical Africa, America, India and China. This study investigated the effect of ethanol leaf extract of B. pinnatum on haematological parameters in Wistar rats induced with chronic inflammation. Fresh green leaves of B. pinnatum were collected from International Center for Ethno-medicine and Drug Development (InterCEDD), Nsukka, Enugu-State, Nigeria. Identification and authentication of the plant was carried and a voucher specimen was deposited at the InterCEDD herbarium. The plant material was then shredded, air-dried under shade and pulverized. The fine powders obtained was weighed and extraction was done via solvent combination of water and ethanol (3:7) for 72 hr via maceration. The filtrate gotten was evaporated to dryness to obtain the ethanol extract which was used for further bioassay study. Chronic inflammation was induced intraperitoneally using cotton pellet and hematological parameters were analyzed using mindray hematology auto analyzer. Results showed a significant increase (p<0.05) in the total white blood cell (TWBC) as well as the red blood cell, haemoglobin and packed cell volume levels in the extract treated groups compared with the control group. The findings of this study showed the reversibility of the induced and suppressive effects of chronic inflammatory disorder on blood cell progenitors. It therefore becomes possible for the adjunct use of B. pinnatum in the management of anemia in chronic inflammatory disorders.
- Chronic disease
- medicinal plants
How to Cite
Mafimisebi TE, Oguntade AE. Preparation and use of plant medicines for farmers’ health in Southwest Nigeria: Socio-cultural, magico-religious and economic aspects. Journal of Ethnobiology and Ethnomedicine. 2010;6(1):1-9.
Salehi B, Kumar NVA, ̧Sener B, Sharifi-Rad M, Kılıç M, Mahady GB, Vlaisavljevic S, Iriti M, Kobarfard F, Setzer WN. Medicinal plants used in the treatment of human immunodeficiency virus. International Journal of Molecular Science. 2018;19:14-59.
Katsiari CG, Bogdanos DP, Sakkas LI. Inflammation and cardiovascular disease. World Journal of Translational Medicine. 2019;8(1):1-8.
Onwubuya EI, Ogbunugafor HA, Okafor CS, Oladejo AA. Acute and chronic anti-inflammatory effect of Bryophyllum pinnatum leaf extract on wistar rats. European Journal of Medicinal Plants. 2021;32(6):6-14.
Onwubuya EI, Oladejo AA. Possible effects of free radical scavengers on dissolution of inflammatory granuloma: An experience with wistar rats. Current Research in Complementary & Alternative Medicine. 20225:149.
Udo EF, Olantunji OI, Abayomi FT, Idowu AM, Abiodun AO. Comparative haematological and serum biochemical evaluation of rats fed with hydro-ethanolic leaves extracts of Moringa oleifera and Telfairia occidentalis. Covenant Journal of Physical & Life Sciences. 2017;5(1):17- 26.
Oladejo AA, Osukoya O. Hematological profiles of naturally infected pigs treated with Bridelia ferruginea leaf extracts. Asian Hematology Research Journal. 2021;4 (2):1-10.
Howida S, Abou S. Physiological changes due to hepatotoxicity and the protective role of some medicinal plants. Beni-Suef University Journal of Basic and Applied Sciences. 2016;5(2):134-146.
Feng Y, Li S, Tan H, Wang N, Zhang Z, Lao L, Wong W. The role of oxidative stress and antioxidants in liver diseases. International Journal of Molecular. Science. 2015;16(1):26087- 20124.
Kyrian-Ogbonna EA, Ekwealor IA, Eze EN, Eluba RA, Nworji EC, Ogah EC, Oladejo AA. Antibiotic resistance patterns of Escherichia coli detected in pig faecal samples from Anambra state. Microbiology Research Journal International. 2021;31 (5):56-63.
Seema VP. Kalanchoe pinnata: Phytochemical and pharmacological profile. International Journal of Pharmaceutical science and Research. 2018;3(4):993 -1000.
Anuradha KP, Shankul K, Iyeri SV, Rahul JS, Vaidya SK. Pharmacognostical, phytochemical and pharmacological review on Bryophyllum pinnata. International Journal of Pharmaceutical and Biological Archives. 2012;3(3):423-433.
Aprioku JS, Igbe I. Effects of aqueous Bryophyllum pinnatum leaf extract on haematological, renal and sperm indices in wistar rats. Indian Journal of Pharmaceutical Sciences. 2017;79(4):521-526.
Okwu DE, Nnamdi FU. Two novel flavonoids from Bryophyllum pinnatum and their antimicrobial activity. Journal of Chemistry and Pharmacology Research. 2011;3(2):1-10.
Muhammad A, Imran K, Ruqaiyah K, Rajbala S, Mohit C, Tanvi B, Firoz A. Bryophyllum pinnatum: A review. International Journal of Research in Biological Sciences. 2012;2(4):143-149.
Nkafamiya II, Maina HM, Osemeahon SA, Modibbo UU. Percentage oil yield and physiochemical properties of different groundnut species (Arachis hypogaea). African Journal of Food Science. 2010;4 (7):418-421.
Goldstein SA, Shemano L, Daweo R, Betler JM. Cotton pellet granuloma pauchmethod for evaluation anti-inflammatory activity. Archives Internationales de Pharmacodynamie et de Therapie. 1967;165:294-301.
Magalhaes P, Appell H, Duarte J. Involvement of advanced glycation and products in the pathogenesis of diabetes complication; the protective role of regular physical activity. European Review of Aging and Physical Activity. 20085:17-29.
Oyedemi SC, Adewusi EA, Aiyegoro CA, Akinpelu DA. Antidiabetic and haematological effect of aqueous extract of stem bark of Afzelia africana (Smith) on streptozotocin-induced diabetic wistar rats. Asian Pacific Journal of Tropical Biomedicine. 2011;1:353-358.
Ahumibe AA, Braide VB. Effect of gavage treatment with pulverized Garcina kola seeds on erythrocyte membrane integrity and selected haematological indices in male albino wistar rats. Nigerian Journal of Physiological Sciences. 2009;24:47-52.
Nwankpa P, Chukwuemeka OG, Ekweogu CN. Investigation of ethanol stem bark extract of treculia africana on the haematological parameters of albino wistar rats. Journal of Biochemistry and Analytical Biochemistry. 2017;6(4):347-351.
Aprioku JS, Obianime, AW. Evaluation of the effects of Citrus aurantifolia (Lime) juice in lead-induced haematological and testicular toxicities in rats. Pharmacologia. 2014;5:36-41.
Zhang W, Fievez L, Cheu E, Bureau F, Rong W, Zhang Y. Antiinflammatory effects of formoterol and ipratropium bromide against acute cadmium-induced pulmonary inflammation in rats. The European Journal of Pharmacology. 2010;628:171-8.
Teguia A, Telefo PB, Fosto RG. Growth performances, organ development and blood parameters of rats fed raded levels of steeped and cooked taro tuber (Esculenta) meal. Livestock Research for Rural Development. 2007;19:1-8.
Esenowo GJ, Sam SM, Bala DN, Ekpo BA, Edung EM. Phytochemical screening and the haematological effect of Peristrophe bicalycuta (RETZ) Nees diet preparation in albino rats. World Journal of Applied Science and Technology. 2010;2:277-281.
Okon JE, Esenowo GJ, Afaha IP, Umoh, NS. Hematopoietic parameters of ethanolic fruits extract of musa accumulate on albino rats. Bulletin of Environment, Pharmacology and Life Sciences. 2013;2:22-26.
Ogbonnia SO, Anyika EN, Mbaka GO, Utah P, Ugwu D. Antihyperglycaemic and antiheperlipidaemic effects of aqueous ethanol extract of Tapinanthus globiferus leaves and Treculia africana root bark and their mixture on alloxan diabetic rats. Agriculture and Biology Journal of North America. 2012;3:237-246.
Mbaka GO, Adeyemi OO, Oremosu AA. Acute and sub-chronic toxicity studies of the ethanol extract of the leaves of Sphenocentrum jollyanum (menispermaceae). Agriculture and Biology Journal of North America. 2010; 1:265-272.
Abstract View: 58 times
PDF Download: 14 times