International Journal of Research and Reports in Hematology https://journalijr2h.com/index.php/IJR2H <p style="text-align: justify;"><strong>International&nbsp;Journal of Research and Reports in Hematology</strong>&nbsp;aims to publish&nbsp;high-quality&nbsp;papers (<a href="/index.php/IJR2H/general-guideline-for-authors">Click here for Types of paper</a>) in all areas of&nbsp;‘Hematology’. This journal facilitates the research and wishes to publish papers as long as they are technically correct, scientifically motivated. The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer-reviewed, open access INTERNATIONAL journal.</p> International Journal of Research and Reports in Hematology en-US International Journal of Research and Reports in Hematology Endometrial Carcinoma: “A Case Report” https://journalijr2h.com/index.php/IJR2H/article/view/30152 <p>Endometrial cancer starts in the layer of cells that make up the uterine lining. Uterine cancer is adenocarcinoma, often known as endometrial cancer A 58year old female from hardona chandrapur admitted in gynecology2021 with known case of endometrial cancer. Uterine cancer is the most commonly diagnosed malignancy of a woman's reproductive system. She is 58kg and her height is 158 cm.</p> <p><strong>Symptoms: </strong>Vaginal bleeding, urinary retention.</p> <p><strong>Clinical Findings:</strong> (Monocytes – 2%), (Granulocytes – 70%), (RDW – 19.6%), (Total protein – 6.2 g/dl), (Albumin – 3.2 g/dl). In physical examination, Inspection of abdomen scar was found on lower abdomen, during palpation tenderness was found in lower quadrant, In genital examination vaginal bleeding was present and inflammation was also present around the genital area. <strong>Diagnosis: </strong>The patient was diagnosed as endometrial cancer.</p> <p><strong>Therapeutic interventions: </strong>Injection Augmentin 1.2 gm IV x TDS, Injection amikacin 500 mg IV x TDS, Injection pantoprazole 40 mg IV x BD, Injection neomol IV x BD, Syrup duphlac2 tsp. orally BD was used.</p> <p><strong>Etiology:</strong> About 75% of endometrial cancer cases are post-menopausal with median age of 60 years. The chances of carcinoma increases if menopause does not occur after the age of 52.</p> <p><strong>Conclusion:</strong> Preventive measures like dilation and curettage (D&amp;C), transvaginal ultrasound, computed tomography (CT or CAT) scan, magnetic resonance imaging (MRI) pelvic examination, endometrial&nbsp;biopsy, counselling is also very important for patients and their family members. My patient shows great improvement after getting the treatment and the treatment was still going on till my last date of care.</p> Aniket Gavankar Jaya Gawai ##submission.copyrightStatement## 2022-01-12 2022-01-12 34 39 Phytochemical Profile and Haematological Indices in Toxicity Studies of Maerua angolensis and Gliricidia sepium Leaves Extracts https://journalijr2h.com/index.php/IJR2H/article/view/30149 <p><strong>Background:</strong> In phytomedicine, plant actions and activities are tied to their molecular build up. Exploiting plant phytochemistry is, therefore, a pointer to its likely medicinal activities. We studied the phytochemical profile of <em>G. sepium</em> and <em>M. angolensis </em>and their haematological interference in Wistar rats during acute and subacute toxicity testing.</p> <p><strong>Methodology: </strong>Standard methods were used for qualitative and quantitative phytochemical evaluation. 100g each of powdered leaves of <em>Gliricidia sepium</em> and <em>Maerua angolensis</em> were soaked in 100ml of Petroleum ether and 70% Ethanol respectively for 48 hours at room temperature. The filtered solutions were concentrated up to 50 ml and were used for the qualitative phytochemistry. Eighteen female rats were used for acute toxicity (limit test). They were divided into three groups (n=6). 2000mg and 5000mg of extract per kg body weight was administered orally to groups 2 and 3 respectively and monitored for 14 days. Group 1 was administered with 0.25ml of distilled water to serve as the control. Fifty Wistar rats (25 males and 25 females) were divided into five groups of equal sexes (n=10) for the subacute testing. Groups 2, 3, 4 and 5 were respectively administered with 125, 250, 500 and 1000mg/kg body weight of extract orally for 28 days<em>.</em> Group 1 was treated as done for the acute study. Animals were anaesthetized and EDTA blood samples were collected through cardiac puncture and processed using Sysmex Xn 1000 auto-analyzer.</p> <p><strong>Results:</strong> Both <em>G. sepium</em> and<em> M. angolensis </em>leaves extracts showed the presence of varieties of medicinal phytochemicals. Seasonal variations have little effect on their quantities and plants harvested during the wet season housed more phytochemicals than that of the dry season. The haematological profiles were not affected during the acute and subacute toxicity evaluation. <em>G. sepium</em> rather boosted the blood production by increasing the population of the circulating erythrocytes and red cell indices.</p> <p><strong>Conclusion:</strong> <em>G. sepium</em> and<em> M. angolensis</em> are candidate plants for medicinal phytochemicals, both extracts did not portray danger to the system and <em>G. sepium</em> extract could even be used for haematoprotective functions.</p> Abdurrasheed Ola Muhammed Immaculate Nakalembe Janet Nakyejwe Luqman O. Olatunbosun Suleiman Ibrahim Eleha ##submission.copyrightStatement## 2022-01-01 2022-01-01 1 14 Annona muricata L. Suppress Carbon Tetra Chloride Effects through Alleviating Hematological Disturbances in Adult Male Rabbits https://journalijr2h.com/index.php/IJR2H/article/view/30150 <p><strong>Background:</strong> <em>Annona muricata.</em> L has many of medicinal properties and has been used widely in traditional medicine for treatment various disorders. Carbon tetrachloride (CCl<sub>4</sub>) is rapidly absorbed by any route of exposure in humans and animals. Once absorbed, it is widely distributed among tissues depending on exposure concentration or dose. This study was designed to find out possible role of <em>A. muricata</em> suppress CCl<sub>4</sub> toxicity through alleviating hematological parameters disturbances in adult male rabbits.</p> <p><strong>Materials and Methods</strong><strong>:</strong> Four rabbits per group were assigned to four groups: 0 mg <em>A. muricata</em> and 0 mg CCl<sub>4</sub>/kg BW (control); 100 mg of <em>A. muricata</em> /kg BW; 0.5 mg CCl<sub>4</sub>/kg BW; 0.5 mg CCl<sub>4</sub> plus 100 mg of <em>A. muricata</em> /kg BW. Rabbits were orally administered the respective doses every other day for 3 weeks.</p> <p><strong>Results:</strong> Treatment with <em>A. muricata</em> were not caused significant effect on values of red blood cells (RBCs), packed cell volume (PCV), hemoglobin (Hb), mean cell hemoglobin (MCH) and mean cell hemoglobin concentration (MCHC). On the other hand CCl<sub>4</sub> was caused increase on values of RBCs, Hb, MCV, and MCHC. Only MCV was significantly decreased with <em>A. muricata</em> alone. The presence of <em>A. muricata</em> with CCl<sub>4 </sub>returned the values of the previous parameters close to the control values. CCl<sub>4</sub> caused high significant increased in mean number of WBCs compared with other three groups among three weeks of experiment. However, treatment with CCl<sub>4</sub> was not yielded significant deference in percentage value of neutrophil or lymphocytes compared to control. The presence of <em>A. muricata</em> with CCl<sub>4</sub> returned mean number of WBCs close to control value. Current results also indicated that treatment with CCl<sub>4 </sub>caused a significant decreased in number of PLT while <em>A. muricata</em> caused increased in the number of PLT compared with control group. Oral administration of CCl<sub>4</sub> induced profound alterations in the morphology of erythrocytes. In rabbit treated with CCl<sub>4</sub> the cells were showed alteration in normal shape to star shaped or sickle cells. The mentioned alterations were less pro-found in animals treated with CCl<sub>4</sub> plus <em>A. muricata</em>. The cells had nearly normal morphology and regular contour, only some erythrocytes (not normal) could be noticed.</p> <p><strong>Conclusion:</strong> Administration of <em>A. muricata</em> L. in combination with CCl<sub>4 </sub>was able to minimize and alleviate the hazardous effect of CCl<sub>4</sub> on most of the measured parameters. So it can be concluded that the presence of <em>A. muricata</em> with CCl<sub>4</sub> counteracted the negative effects of CCl<sub>4</sub> on hematological parameters in male rabbit.</p> Marfoua. S. Ali Fayrouz. A. khaled Aiman S. Abuajaila ##submission.copyrightStatement## 2022-01-03 2022-01-03 15 26 Predictive Significance of Mean Platelet Volume and Platelet Distribution Width Level in Immune Thrombocytopenia Patients Treated With Steroids https://journalijr2h.com/index.php/IJR2H/article/view/30151 <p><strong>Background:</strong> Immune thrombocytopenia is an acquired thrombocytopenia caused by autoantibodies against platelet antigens. Immune thrombocytopenia is usually observed more common in famale. Many patients with Immune thrombocytopenia are asymptomatic. Those with symptoms are primarily related to thrombocytopenia and bleeding, but patients may also experience fatigue and reduced quality of life. The purpose of treatment in an Immune thrombocytopenia patient is not to normalize the platelet count, but to treat or prevent bleeding. For this purpose, steroids are an important part of the treatment in the first place. In our study, pretreatment hemogram parameters, especially Mean Corpuscular Volume and platelet distribution width values, were investigated in patients with immune thrombocytopenia, whether they were predictive values for immune thrombocytopenia.</p> <p><strong>Materials and Methods: </strong>Hemogram parameters of 222 Immune thrombocytopenia patients who received steroids as first line therapy were retrospectively scanned.</p> <p><strong>Results: </strong>A statistically significant difference was determined between the first and last measurements in terms of hemoglobin, mean corpuscular volüme, white blood cell, neutrophil and platelet variables. There is an increase in hemoglobin, mean corpuscular volüme, white blood cell, neutrophil and platelet values after the procedure (ie at the last measurement) compared to the first measurement. It can be said that there is a very high level of positive correlation between neutrophil and white blood cell. After the treatment a negative correlation was detected between platelet value and mean platelet volüme, platelet distribution width values. According to the results of the correlation analysis before the treatment, a positive corr elation was found between the platelet value and the mean platelet volüme value. While there is a positive correlation between platelet and mean platelet volüme values before the treatment, it is seen that there is a negative correlation between these values after the treatment</p> <p><strong>Conclusion:</strong> It has been concluded that mean platelet volüme and platelet distribution width values cannot be used as a predictive value in the response of disease before steroid treatment in Immune thrombocytopenia patients.</p> Ahmet Kaya İrfan Kuku Mehmet Ali Erkurt Emin Kaya İlhami Berber Ahmet Sarıcı Soykan Biçim Emine Hidayet Fatma Hilal Yağin Ayşe Uysal ##submission.copyrightStatement## 2022-01-08 2022-01-08 27 33