International Journal of Research and Reports in Hematology https://journalijr2h.com/index.php/IJR2H <p style="text-align: justify;"><strong>International&nbsp;Journal of Research and Reports in Hematology</strong>&nbsp;aims to publish&nbsp;high-quality&nbsp;papers (<a href="/index.php/IJR2H/general-guideline-for-authors">Click here for Types of paper</a>) in all areas of&nbsp;‘Hematology’. This journal facilitates the research and wishes to publish papers as long as they are technically correct, scientifically motivated. The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer-reviewed, open access INTERNATIONAL journal.</p> en-US contact@journalijr2h.com (International Journal of Research and Reports in Hematology) contact@journalijr2h.com (International Journal of Research and Reports in Hematology) Fri, 27 Mar 2020 12:44:27 +0000 OJS 3.1.1.4 http://blogs.law.harvard.edu/tech/rss 60 Splenomegaly and Gaucher Disease https://journalijr2h.com/index.php/IJR2H/article/view/30117 <p>Gaucher disease is an autosomal recessive genetic disorder caused by a deficiency of a lysosomal enzyme, β-glucocerebrosidase, which is responsible for the accumulation of glucosylceramide in the lysosomes of macrophages in the liver, spleen and bone marrow. Clinical expression is highly variable from cytopenia, osteoarticular to neurological manifestations, resulting in delayed diagnosis. Diagnosis can be made by measuring the activity of β-glucocerebrosidase, the myelogram or osteomedullary biopsy, and treatment is essentially medical, based on enzyme replacement therapy.</p> <p>Splenectomy is considered in situations where haematological complications are in the foreground, such as hypersplenism, haemorrhagic syndrome, or a symptomatic large splenomegaly.</p> <p>We report the case of a 45-year-oldmalewith arthralgia and a large spleen whose myelogram and osteo-medullary biopsy was in favour of Gaucher disease. In the face of hypersplenism and symptomatic enlarged spleen, a total splenectomy was performed. The histological study showed the accumulation of substances called glucocerebrosides inside the lysosomes of cells in the macrophagic system.</p> Taoufik Elabbassi, Harouna Bonkoukou Abdoulaye, Mohamed Ouchane, Mohamed Rachid Lefriyekh ##submission.copyrightStatement## https://journalijr2h.com/index.php/IJR2H/article/view/30117 Mon, 04 May 2020 00:00:00 +0000 Rhesus E, Rhesus D and ABO Blood Groups Distribution among Indigenes of Ogoni Ethnic Group of Rivers State, Nigeria https://journalijr2h.com/index.php/IJR2H/article/view/30116 <p><strong>Aim: </strong>The aim of the study was to determine the percentage distribution of Rhesus E, Rhesus D and ABO blood groups among indigenes of Ogoni ethnic group of Rivers State, Nigeria.</p> <p><strong>Study Design:</strong>&nbsp; This was a cross-sectional study carried out among indigenes of Ogoni whose origin of their first generation parents is Ogoni. A total of 101 subjects (49 females and 52 males), within the ages of 30–60 years were recruited for the study and they were apparently healthy.</p> <p><strong>Place and Duration of Study:</strong> Ogoniland is located in an area along the Niger Delta Eastern edge, and to the north-east of the Imo River and Port Harcourt city. Ogoniland covers about 1036 Sq Km and borders the Bay of Guinea. All participants were recruited in Bori. Bori is the traditional headquarter of Ogoni. Bori is located on latitude: 4<sup>0</sup>40ʹ34.64ʺ N and longitude: 7<sup>0</sup>21ʹ54.68ʺE. Laboratory analysis was carried out at the Post Graduate Laboratory of Rivers State University, Nkpolu-Oroworukwo, Port Harcourt, Rivers State, Nigeria. Port Harcourt, the capital of Rivers State, is located on latitude 4.75<sup>0</sup>N and longitude 7.00<sup>0</sup>E and lies along Bonny River in the Niger Delta. All subjects were recruited on the same day and their blood samples collected on 2nd October, 2019, and analysis performed on 3<sup>rd</sup> October, 2019.</p> <p><strong>Methodology:</strong> Determination of ABO and Rhesus D blood groups was done using Anti-A, Anti-B, and Anti-D IgD/IgM Blend Reagents, manufactured by Atlas Medicals, Cambridge-UK, Lot No[s] 19031214; 19030910; 19031921; Expiry Dates: 2021/03/16; 2021/03/10; 2021/03/20 and phenotyping of red cells was carried out manually using standard tube techniques as described by Judd, and Brecher. Determination of Rhesus E blood group was done using Anti-E Monoclonal, manufactured by Lorne Laboratories Ltd, UK. Lot No: 69189-A4; Expiry Date: 2021/03/04. Phenotyping of red cells was done using tube method as described by Lorne Laboratory Ltd.</p> <p><strong>Results:</strong> The result revealed percentage distribution of 22.77% for blood group A; 20.79% for blood group B; 52.47% for blood group O; 3.96% for blood group AB; 92.07% for Rhesus D positive blood group; and 25.74% for Rhesus E positive blood group amongst the Ogonis. The study revealed that ABO blood group percentage distribution among the Ogonis was in the order of O &gt; A &gt; B &gt; AB (blood group O being the predominant ABO blood group followed by blood group A, blood group B, and blood group AB.</p> <p><strong>Conclusion: </strong>The study has revealed the presence of Rhesus E antigen in the Ogoni populace. It is therefore necessary to take into cognizance the fact that the presence of Rhesus E antigen may likely be the cause of some transfusion reactions which cannot be explained after a compatible ABO and Rhesus D cross match. We therefore recommend that routine typing of Rhesus E blood group be done on blood donors and recipients before blood transfusion.</p> Serekara Gideon Christian, Evelyn Mgbeoma Eze, Anthony Chijioke Uzoanya Ezimah, Fiekumo Igbida Buseri ##submission.copyrightStatement## https://journalijr2h.com/index.php/IJR2H/article/view/30116 Fri, 27 Mar 2020 00:00:00 +0000 Consumption of Tiger Nut (Cyperus esculentus L.) Improves Haematopoiesis in Wistar Rats https://journalijr2h.com/index.php/IJR2H/article/view/30118 <p><strong>Background:</strong> The consumption of tiger nut has often been relegated only to the poor due to its affordability.</p> <p><strong>Aim:</strong> This study is therefore aimed at assessing its effect on haematological parameters in Wistar rats.</p> <p><strong>Materials and Methods: </strong>Twenty-four adult Wistar rats were divided into four groups of six each. Animals in group A were administered normal saline solution while those in groups B, C and D were administered 1, 2 and 4 mL/kg body weight of undiluted tiger nut<strong>&nbsp; </strong>milk respectively for twenty-eight days. The administration was done 12 hourly <em>via</em> the oral route. At the end of the administration, the rats were sacrificed after an overnight fast under diethyl ether as anesthesia. Blood samples were collected <em>via</em> cardiac puncture. Haematological parameters were determined using standard methods.</p> <p><strong>Results:</strong> A dose-dependent increase was observed in packed cell volume (PCV), haemoglobin (Hb), red blood cell (RBC) and mean corpuscular haemoglobin concentration (MCHC) of animals treated with tiger nut milk when compared with those in animals in the control group. The increase was significant (p&lt;0.05) at all instances except in the PCV of animals treated with 1 mL/kg body weight of tiger nut milk that were not significantly different from those in control animals. However, tiger nut milk had no significant (p&lt;0.05) effect on mean corpuscular volume (MCV) and mean corpuscular haemoglobin (MCH) when compared with those in control animals. Tiger nut milk administration was observed to increase white blood cell (WBC), lymphocyte, neutrophil and platelet in a dose-dependent manner when experimental animals were compared with those in the control group. The increase was significant (p&lt;0.05) at all instances except in the lymphocyte and neutrophil of animals treated with 1 mL/kg body weight of tiger nut milk that were not significantly (p&lt;0.05) different from those in control animals.</p> <p><strong>Conclusion: </strong>Results of this present study indicate that tiger nut possesses haematopoietic properties and can be used to boost blood levels especially in anaemia patients. Furthermore, the plant possessed the ability to boost the immune system and thus defend the body against xenobiotics.</p> Augustine Ikhueoya Airaodion, Emmanuel Onyebuchi Ogbuagu ##submission.copyrightStatement## https://journalijr2h.com/index.php/IJR2H/article/view/30118 Tue, 11 Aug 2020 00:00:00 +0000