Comparison of Platelet Rich Fibrin over Platelet Rich Plasma: A Current Review
Published: 2024-07-11
Page: 73-80
Issue: 2024 - Volume 7 [Issue 2]
Ramjeela S
*
Srinivas University, Mangalore, Karnataka, India.
Sukesh
Department of Pathology, Srinivas Institute of Medical Sciences and Research Centre, Mangalore, Karnataka, India.
Swathi D
Department of Forensic Sciences, Institute of Allied Health Sciences, Srinivas University, Mangalore, Karnataka, India.
*Author to whom correspondence should be addressed.
Abstract
Clinical applications have been made of platelet rich fibrin (PRF), a platelet concentrate that can promote tissue regeneration. It's interesting to note that despite numerous techniques being put forth, not much information has been found about the final cell counts after centrifugation. There are several centrifuges that are commercially available with their corresponding procedures using a new technique for cell quantification. Platelet concentrates, such as platelet-rich fibrin (PRF) and platelet-rich plasma (PRP), have been used extensively as a scaffold to promote tissue regeneration in numerous medical specialties. PRP was initially presented as a specialized restorative technique meant to concentrate entire blood platelets. The aim of this study was to compare the effectiveness of PRP and PRF.
Keywords: Platelet concentrates, platelet rich plasma, platelet rich fibrin, secretory proteins, leucocyte-poor platelet rich plasma, advanced rich plasma plus
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References
Mihaylova Z, Mitev V, Stanimirov P, Isaeva A, Gateva N, Ishkitiev N. Use of platelet concentrates in oral and maxillofacial surgery: an overview. Acta Odontol Scand. 2017; 75(1):1–11.
Marques LF, Stessuk T, Camargo IC, Sabeh Junior N, dos Santos L, et al. Platelet-rich plasma (PRP): methodological aspects and clinical applications. Platelets. 2015;26(2):101–13.
Frey miller EG, and Marx R. Platelet-rich plasma: Evidence to support its use [2] (multiple letters). J Oral Maxillofac Surg, 2004; 62 1046–1048.
Ehrenfest DMD, Bielecki T, Corso MD, et al. Shedding light in the controversial terminology for platelet-rich products: Platelet-rich plasma (PRP), platelet-rich fibrin (PRF), platelet-leukocyte gel (PLG), preparation rich in growth factors (PRGF), classification and commercialism. J Biomed Mater Res A. 2010;95:1280–1282.
Priya N. Platelet rich plasma: clinical applications of PRP in dentistry. IOSR J Dent Med Sci, 2014;13:41–43.
Miron RJ, Fujioka-Kobayashi M, Bishara M, et al. Platelet-rich fibrin and soft tissue wound healing: a systematic review. Tissue Eng Part B Rev. 2017;23:83–99.
Anitua E, Murias-Freijo A, Alkhraisat MH, et al. Clinical, radiographical, and histological outcomes of plasma rich in growth factors in extraction socket: A randomized controlled clinical trial. Clin Oral Investig. 2015;19:589–600.
Kobayashi E, Flückiger L, Fujioka-Kobayashi M, Sawada K, Sculean A, Schaller B, et al. Comparative release of growth factors from PRP, PRF, and advanced-PRF. Clin Oral Investig. 2016; 20(9):2353–60.
Knezevic NN, Candido KD, Desai R, Kaye AD. Is platelet-rich plasma a future therapy in pain management? Med Clin North Am. 2016;100(1):199–217.
Tözüm TF and Demiralp B. Platelet-rich plasma: a promising innovation in dentistry. J Can Dent Assoc. 2003;69: 664.
Borie E, Oliví DG, Orsi IA, et al. Platelet-rich fibrin application in dentistry: a literature review. Int J Clin Exp Med. 2015;8:7922–7929.
Bielecki T, Dohan Ehrenfest DM. Platelet-rich plasma (PRP) and Platelet-Rich Fibrin (PRF): surgical adjuvants, preparations for in situ regenerative medicine and tools for tissue engineering. Curr Pharm Biotechnol. 2012;13:1121–1130.
Dohan Ehrenfest DM, Rasmusson L, Albrektsson T. Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L- PRF) Trends Biotechnol. 2009;27:158–167.
Cieslik-Bielecka A, Choukroun J, Odin G, Dohan Ehrenfest DM. L-PRP/L-PRF in esthetic plastic surgery, regenerative medicine of the skin and chronic wounds. Curr Pharm Biotechnol. 2012; 13:1266–1277.
Anitua E, Sanchez M, Orive G, Andia I. The potential impact of the preparation rich in growth factors (PRGF) in different medical fields. Biomaterials. 2007;28:4551–4560.
Puzzitiello RN, Patel BH, Forlenza EM, Nwachukwu BU, Allen AA, Forsythe B, Salzler MJ. Adverse Impact of Corticosteroids on Rotator Cuff Tendon Health and Repair: A Systematic Review of Basic Science Studies. Arthrosc. Sports Med. Rehabil. 2020;2:e161– e169.
Everts PA, Hoffmann J, Weibrich G, et al. Differences in platelet growth factor release and leucocyte kinetics during autologous platelet gel formation. Transfus Med. 2006;16:363–368.
Everts PA, Hoogbergen MM, Weber TA, Devilee RJ, van Monftort G, de Hingh IH. Is the use of autologous platelet-rich plasma gels in gynecologic, cardiac, and general, reconstructive surgery beneficial? Curr Pharm Biotechnol. 2012;13:1163–1172.
Lana JF, Macedo A, Ingrao ILG, Huber SC, Santos GS, Santana MHA. Leukocyte-rich PRP for knee osteoarthritis: Current concepts. J. Clin. Orthop. Trauma. 2019;10:S179–S182.
Narayanaswamy R, Sha I. Arthroscopic Meniscal Repair with Second-Generation Platelet-Rich Fibrin Clot Augmentation. Arthrosc. Tech. 2022;11:e1569–e1575.
Marx RE. Platelet-rich plasma: Evidence to support its use. J Oral Maxillofac Surg. 2004; 62:489–96.
Wang Z, Han L, Sun T, Wang W, Li X, Wu B. Preparation and Effect of Lyophilized Platelet-Rich Fibrin on the Osteogenic Potential of Bone Marrow Mesenchymal Stem Cells in Vitro and in Vivo. Heliyon. 2019;5:e02739.
Dohan DM, Choukroun J, Diss A, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101:e37–44.
Cieslik-Bielecka A, Gazdzik TS, Bielecki TM, Cieslik T. Why the platelet-rich gel has antimicrobial activity? Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;103:303–305.
Cieslik-Bielecka A, Bielecki T, Gazdzik TS, Arendt J, Krol W, Szczepanski T. Autologous platelets and leukocytes can improve healing of infected high-energy soft tissue injury. Transfus Apher Sci. 2009;41:9–12.
Dohan Ehrenfest DM, de Peppo GM, Doglioli P, Sammartino G. Slow release of growth factors and thrombospondin-1 in Choukroun’s platelet-rich fibrin (PRF): a gold standard to achieve for all surgical platelet concentrates technologies. Growth Factors. 2009;27:63–69.
Dohan DM, Choukroun J, Diss A, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part II: platelet-related biologic features. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101:e45–50.
Weibrich G, Kleis WK, Kunz-Kostomanolakis M, Loos AH, Wagner W. Correlation of platelet concentration in platelet-rich plasma to the extraction method, age, sex, and platelet count of the donor. Int J Oral Maxillofac Implants. 2001;16:693–699.
Gibble JW, Ness PM. Fibrin glue: the perfect operative sealant? Transfusion. 1990; 30:741–747.
Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, et al. Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part I: technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101(3):e37–44.
Dohan Ehrenfest DM, Rasmusson L, Albrektsson T. Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF). Trends Biotechnol. 2009;27(3):158–67.
Ghanaati S, Booms P, Orlowska A, Kubesch A, Lorenz J, Rutkowski J, et al. Advanced platelet-rich fibrin: a new concept for cell-based tissue engineering by means of inflammatory cells. J Oral Implantol. 2014;40(6):679–89.
Jameson CA. Autologous platelet concentrates for the production of platelet gel. Lab Med. 2007;38(1):39–42.
Gurtner GC, Werner S, Barrandon Y, Longaker MT. Wound repair and regeneration. Nature. 2008;453(7193): 314–21.
Barbon S, Stocco E, Macchi V, Contran M, Grandi F, Borean A, et al. Platelet-rich fibrin scaffolds for cartilage and tendon regenerative medicine: from bench to bedside. Int J Mol Sci. 2019; 20(7):1701.
Fujioka-Kobayashi M, Miron RJ, Hernandez M, Kandalam U, Zhang Y, Choukroun J. Optimized platelet-rich fibrin with the low-speed concept: growth factor release, biocompatibility, and cellular response. J Periodontol. 2017; 88(1):112–21.
Kobayashi E, Flückiger L, Fujioka-Kobayashi M, Sawada K, Sculean A, Schaller B, et al. Comparative release of growth factors from PRP, PRF, and advanced-PRF. Clin Oral Investig. 2016; 20(9):2353–60.
Sinder BP, Pettit AR, McCauley LK. Macrophages: their emerging roles in bone. J Bone Miner Res. 2015; 30(12):2140–9.
Shah R, Thomas MGT, Mehta R, A DS. Update on the protocols and biologic actions of platelet rich fibrin in dentistry. Eur J Prosthodont Restor Dent. 2017; 25(2):64–72.
Mourão CF, Valiense H, Melo ER, Mourão NB, Maia MD. Obtention of injectable platelets rich-fibrin (i-PRF) and its polymerization with bone graft: technical note. Rev Col Bras Cir. 2015; 42(6):421–3.
Bowen RA, Remaley AT. Interferences from blood collection tube components on clinical chemistry assays. Biochem Med. 2014;24(1):31–44.
Miron RJ, Fujioka-Kobayashi M, Hernandez M, Kandalam U, Zhang Y, Ghanaati S, et al. Injectable platelet rich fibrin (i-PRF): opportunities in regenerative dentistry? Clin Oral Investig. 2017; 21(8):2619–27.
Tunalı M, Özdemir H, Küçükodacı Z, Akman S, Yaprak E, Toker H, et al. A novel platelet concentrate: titanium-prepared platelet-rich fibrin. Biomed Res Int. 2014;2014:209548.
Sohn DS, Huang B, Kim J, Park WE, Park CC. Utilization of autologous concentrated growth factors (CGF) enriched bone graft matrix (sticky bone) and CGF-enriched fibrin membrane in implant dentistry. J Implant Advanced Clin Dent. 2015; 7(10):11–8.
Sohn DS, Huang B, Kim J, Park WE, Park CC. Utilization of autologous concentrated growth factors (CGF) enriched bone graft matrix (sticky bone) and CGF-enriched fibrin membrane in implant dentistry. J Implant Advanced Clin Dent. 2015; 7(10):11–8.
Cakir S, Gultekin BA, Karabagli M, Yilmaz TE, Cakir E, Guzel EE, Yalcin S, Mortellaro C, Mijiritsky E. Histological Evaluation of the Effects of Growth Factors in a Fibrin Network on Bone Regeneration. J. Craniofacial Surg. 2019;30:1078– 1084.
Ferrara N. The Role of the VEGF Signaling Pathway in Tumor Angiogenesis. In: Marmé D., editor. Tumor Angiogenesis: A Key Target for Cancer Therapy. Springer International Publishing; Cham, Switzerland: 2019;211–226.
Oberlohr V, Lengel H, Hambright WS, Whitney KE, Evans TA, Huard J. Biologics for Skeletal Muscle Healing: The Role of Senescence and Platelet-Based Treatment Modalities. Oper. Tech. Sports Med. 2020;28:150754.
Georgakopoulos I, Tsantis S, Georgakopoulos P, et al. The impact of platelet rich plasma (PRP) in osseointegration of oral implants in dental panoramic radiography: texture based evaluation. Clin Cases Miner Bone Metab. 2014;11:59–66.
Thor A, Wannfors K, Sennerby L, et al. Reconstruction of the severely resorbed maxilla with autogenous bone, platelet-rich plasma, and implants: 1-year results of a controlled prospective 5-year study. Clin Implant Dent Relat Res. 2005;7:209–220.
Gentile P, Calabrese C, De Angelis B, Dionisi L, Pizzicanella J, Kothari A, De Fazio D, Garcovich S. Impact of the Different Preparation Methods to Obtain Autologous Non-Activated Platelet-Rich Plasma (A-PRP) and Activated Platelet-Rich Plasma (AA-PRP) in Plastic Surgery: Wound Healing and Hair Regrowth Evaluation. Int. J. Mol. Sci. 2020;21:431.
Samadi P, Sheykhhasan M, Khoshinani HM. The Use of Platelet-Rich Plasma in Aesthetic and Regenerative Medicine: A Comprehensive Review. Aesthetic Plast. Surg. 2018;43:803–814.
The GRIP (Groupe de Recherche sur les Injections de PRP, PRP Injection Research Group) Eymard PA, Ornetti P, Maillet J, Noel É, Adam P, Legré-Boyer V, Boyer T, Allali F, Gremeaux V, et al. Intra-articular injections of platelet-rich plasma in symptomatic knee osteoarthritis: A consensus statement from French-speaking experts. Knee Surg. Sports Traumatol. Arthrosc; 2020.
Xu J, Gou L, Zhang P, Li H, Qiu S. Platelet-rich plasma and regenerative dentistry. Aust. Dent. J. 2020;65: 131–142.
Nacopoulos C, Vesala A-M. Lower facial regeneration with a combination of platelet-rich fibrin liquid matrices based on the low speed centrifugation concept-Cleopatra technique. J Cosmet Dermatol. 2020; 19:185–9.
Shivashankar VY, Johns DA, Maroli RK, Sekar M, Chandrasekaran R, Karthikeyan S, Renganathan SK. Comparison of the effect of PRP, PRF and induced bleeding in the revascularization of teeth with necrotic pulp and open apex: A triple blind randomized clinical trial. J. Clin. Diagn. Res. 2017;11:ZC34–ZC39.
Panda S, Doraiswamy J, Malaiappan S, Varghese SS, Del Fabbro M. Additive effect of autologous platelet concentrates in treatment of intrabony defects: A systematic review and meta-analysis. J. Investig. Clin. Dent. 2016;7:13–26.