Predictive Values of NLR, PLR and MPV for Pre-Eclampsia in Pregnancy: A Retrospective Cross-Sectional Study in a Teaching Hospital, Ghana
Published: 2022-12-14
Page: 310-319
Issue: 2022 - Volume 5 [Issue 2]
Kofi Mensah
Department of Haematology, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana and Department of Medical Laboratory Sciences, Faculty of Health Science and Technology, Ebonyi State University, Abakaliki, Nigeria.
Charles Nkansah *
Department of Haematology, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana and Department of Medical Laboratory Sciences, Faculty of Health Science and Technology, Ebonyi State University, Abakaliki, Nigeria.
Samuel K. Appiah
Department of Haematology, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana and Department of Medical Laboratory Sciences, Faculty of Health Science and Technology, Ebonyi State University, Abakaliki, Nigeria.
Juliana Barnie
Department of Biomedical Laboratory Science, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana.
Doris T. Timbilla
Department of Biomedical Laboratory Science, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana.
Samira Daud
Department of Haematology, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana.
Dorcas Serwaa
Department of Obstetrics and Gynecology, C4C Homeopathic Medical College, Greater Accra, Ghana.
Felix Osei-Boakye
Department of Medical Laboratory Technology, Faculty of Applied Science and Technology, Sunyani Technical University, Sunyani, Ghana.
Charles A. Derigubah
Department of Medical Laboratory Technology, School of Applied Science and Arts, Bolgatanga Technical University, Bolgatanga, Ghana.
Simon B. Bani
Department of Biomedical Laboratory Science, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana.
Gabriel Abbam
Department of Haematology, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana.
*Author to whom correspondence should be addressed.
Abstract
Aim: To assess the predictive values of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and mean platelet volume (MPV) for pre-eclampsia in pregnancy.
Study Design: Retrospective cross-sectional study.
Place and Duration of Study: Obstetrics and Gynecology unit of Tamale Teaching Hospital, Tamale, Ghana from 1st January, 2021 to 31st December, 2021.
Methodology: The study recruited 161 pregnant women (79 pre-eclamptic pregnant women and 82 apparently healthy pregnant women as controls). Full blood count parameters were assessed using fully automated haematology analyzer. Neutrophil/lymphocyte ratio, and platelet/lymphocyte ratio were calculated. Data analysis was done with SPSS version 22.0 and P<0.05 was considered statistically significant.
Results: Pregnant women with PE had lower parity (P< .001) and gestational ages (P< .001) than their counterparts without PE. Haemoglobin (P= .007), red blood cells (P= .003), haematocrit (P= .01), absolute monocyte (P= .001) and MPV (P= .02) were significantly higher in the PE group compared to the controls. Also, pregnant women with PE had relatively higher MPV compared with the apparently healthy pregnant women without pre-eclampsia (P= .02), but NLR and PLR were not different between the two groups. Again, MPV significantly predicted PE (AUC: 0.609, P< .02) in pregnancy than NLR and PLR.
Conclusion: Lower parity and gestational ages are significantly associated with pre-eclampsia. Hb, RBC, HCT, absolute monocyte count and MPV were higher in pre-eclamptic pregnant women. MPV is a better marker for predicting asymptomatic PE in pregnancy. NLR and PLR did not significantly predict PE in pregnancy.
Keywords: Haematological profile, predictability, pre-eclampsia, NLR, PLR, MPV