Ano Rectal Plasmablastic Lymphoma in HIV Positive Patient - A Case Report

Temesgen Assefa Ayele *

Department of Internal Medicine, Hematology Unit, Saint Peter Specialized Hospital, Ethiopia.

Ephrem Haile Gebreyesus

Department of Internal Medicine, Hematology Unit, Adissababa University, Ethiopia.

*Author to whom correspondence should be addressed.


Plasmablastic lymphoma (PBL) is an aggressive subtype of non-Hodgkin’s lymphoma (NHL), classified as a distinct entity by the WHO (2008) which frequently arises in the oral cavity of HIV infected patients [1]. It is usually associated with EBV infections, and MYC gene rearrangements [2]. PBL remains a diagnostic and a therapeutic challenge with high rate of relapse and death. There is no standard of care for this entity; current understanding & knowledge of PBL relies primarily on case reports and small case series.

We present a case of primary Ano rectal plasmablastic Lymphoma in a 24 years old male HIV positive patient from Ethiopia who presented with a 3 months history rectal bleeding & abdominal pain.

Keywords: Plasmablastic lymphoma, anorectal, HIV

How to Cite

Ayele , T. A., & Gebreyesus , E. H. (2023). Ano Rectal Plasmablastic Lymphoma in HIV Positive Patient - A Case Report. International Journal of Research and Reports in Hematology, 6(2), 228–232. Retrieved from


Jorge J.Castillo etal, The biology and treatment of plasmablastic lymphoma review article, Blood. 2015;125(15):2323–2330.

Jenique Bailly et al Plasma blastic Lymphoma an update, Int J Lab Hematol. Dec 2022;44(6):1121.

3.Knowels DM,Etiology and pathogenesis of AIDS related Lymphoma, Hematol Oncol Clin North Am. Jun 2003;17(3):785-820.

4.Castillo JJ et al., Prognostic factors in chemotherapy treated patients with HIV associated Plasmablastic Lymphoma, Oncologist . 2010;15(3):293-9.

Xibu Liu et al, Anal lymphoma: a tumor with insufficient attention. Discov Oncol. Dec 2023;14:88.

Elyamany G, Alzahrani AM, Aljuboury M et al. Clinicopathologic features of plasmablastic lymphoma: Single-center series of 8 cases from Saudi Arabia. Diagn Pathol 2015;10(78).

Harmon et al., Plasmablastic Lymphoma: A review of clinicopathologic features & differential diagnosis, Archives of Pathology & lab medicine. Arch Pathol Lab Med Oct 2016;140(10):1074-8.

Lynette Luria et al., Manifestation of Gastrointestinal plasmablastic Lymphoma: A case series with literature review. World J Gastroenterol. Sep 7 2014;20(33): 11894–11903.

Elyamany et al Plasmablastic lymphoma: A review of current knowledge & future directions, review article, Adv Hematol. 2015;2015: 315289.

Ando etal, Bortezomib and Lenalidomide based treatment of refractory plasmablastic lymphoma, Oncology research & treatment. Oncol Res Treat. 2020;43(3):112–116.